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There’s no more iconic shape in biology than the twisting strands of DNA. Yet that same double helix that makes the molecule instantly recognizable may also be the very thing holding back cheaper, safer, and more effective forms of gene therapy, according to new research.
But foreign DNA used as a treatment can also trigger the innate immune system’s alarm bells, an insurmountable hurdle for scientists trying to develop gene therapies that don’t rely on engineered viruses, which have their own cost, safety and efficacy issues.
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