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Biotech rally mints huge profits for hedge funds

Wave of M&A fuels rally as big pharma groups hunt for blockbusters ahead of patent cliff

Hedge funds betting on drugs stocks have made bumper profits this year, as a recent wave of deals by big pharmaceutical companies drives the biggest rally in the biotechnology sector in a decade.

New York-based investment manager Perceptive Advisors has seen its flagship $4.5bn hedge fund soar 75 per cent this year to the end of November, according to people who had seen the numbers. Meanwhile, Caligan Partners, another New York-based hedge fund, which manages more than $1bn, was up 92 per cent, its best year since inception in 2022.

The gains come as the Nasdaq Biotechnology index has soared by about one-third, its strongest year since 2014. It has been helped by a renewed surge in dealmaking as big groups looking for their next blockbuster drug spend billions of dollars on biotech companies at the forefront of innovation.

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