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New Novo drug delivers significant weight-loss benefits in diabetes trial

Amycretin also improved participants’ blood sugar levels in positive sign for Danish company’s treatment pipeline

Novo Nordisk’s new obesity drug led to statistically significant weight loss and blood sugar improvements in people with diabetes, a trial has found, in a positive sign for the Danish company’s treatment pipeline.

Patients with type 2 diabetes using amycretin lost up to 14.5 per cent of their body weight, compared with 2.6 per cent for those on a placebo. The drug also reduced blood sugar levels, with about 90 per cent of participants in the stage 2 trial reporting blood glucose levels below 7 per cent. The normal range is below 6 per cent.

The new drug combines semaglutide, the active ingredient in Novo’s diabetes and obesity blockbusters Ozempic and Wegovy, with amylin, a hormone that promotes a feeling of fullness.

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